Is Natura Bissé Oxygen Cream Worth the Splurge?

Ingredient Science
It claims to flood your skin with oxygen molecules — but can a cream actually deliver breathable air to your cells?
Expert Analysis · Honest Reviews · Real Results
1.🫨Oxygen in a Jar?

Sounds like pseudoscience bullshit, right? I thought so too.

Until I woke up after 4 hours of sleep and my coworker asked if I’d gotten a facial. That’s the kind of specific that makes you ignore the red flags.

2.💰What You’re Actually Buying

It’s a $280 moisturizer from Natura Bissé. The claim: a “perfluorocarbon” molecule carries oxygen directly into your skin cells. Like a tiny scuba tank for your face.

1

Oxygen Delivery System

Perfluorocarbons bind to oxygen in the air and release it onto your skin. Not magic. Chemistry.

2

Texture Shift

It’s a gel-cream hybrid. Disappears in 15 seconds. No grease slick.

3

The Scent

Smells like a very expensive spa that hates poor people. I secretly love it.

photo of assorted makeup products on gray surface

Photo: Element5 Digital / Unsplash

3.🧪The Ingredient Reality Check

Three things do the heavy lifting here. One of them is actually wild. The oxygen thing is real — but it’s not the only reason this works.

  • Perfluorodecalin: The oxygen taxi — carries O2 into lower skin layers
  • Shea Butter: Not bougie, but locks everything in without clogging
  • Vitamin E: Stops the oxygen from oxidizing your face (smart)
  • Caffeine: Depuffing in 3 minutes. Great for hangovers.
white and black plastic bottle beside white heart shaped ornament

Photo: Viva Luna Studios / Unsplash

4.🧴How It Feels + 3 Week Update

First pump: watery gel that melts into nothing. I almost panicked — did I even put it on? Then my skin felt… cool. Not tingly. Cool. Like a breath mint for your face.

Week 3: The glow is real. But here’s the catch — if you’re dehydrated, this won’t fix it. You need a hydrating serum underneath or it’s just pretty air.

💡

One Thing: Use it as a daytime finisher over a hyaluronic serum. Nighttime alone? Not enough for dry skin.
woman with white face mask holding green fruit

Photo: Kimia Zarifi / Unsplash

5.🔍Did My Face Actually Change?

Yes. But not in the way you think. My fine lines didn’t vanish. My pores didn’t disappear. But my skin stopped looking tired. That dull, “I’ve been staring at screens for 10 years” thing? Gone by day 4.

Buy if
You’re 35+ and your skin looks tired no matter how much you sleep
⏭️

Skip if
You’re oily and want matte — this gives glow, not shine control
💰

Worth it?
$280 is insane. But a jar lasts 4 months. $70/month for that glow? I’ve spent more on worse.
white round plastic container on brown woven basket

Photo: Poko Skincare / Unsplash

6.🎯Final Call

It’s not a miracle. But it’s the closest thing I’ve found to “instant well-rested” in a jar. Buy it for the days you need to fake 8 hours of sleep.

8.2/10
Expensive air that actually works
🛍️

Where to Buy: Neiman Marcus or the brand site directly. Get the travel size first ($95) — you’ll know by week 1 if it’s for you.